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231: David A. Sinclair | Anti-Aging Research And Understanding In "Lifespan"

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When it comes to anti-aging research, Dr. David A. Sinclair of Harvard Medical School is on the forefront of research and innovation. He joins on episode 231 to discuss his new book “Lifespan: Why We Age – and Why We Don’t Have To”.

Dr. Sinclair, Ph.D., A.O. is a Professor in the Department of Genetics and co-Director of the Paul F. Glenn Center for the Biology of Aging at Harvard Medical School. He is best known for his work on understanding why we age and how to slow its effects. He obtained his Ph.D. in Molecular Genetics at the University of New South Wales, Sydney in 1995. He worked as a postdoctoral researcher at M.I.T. with Dr. Leonard Guarente where he co discovered a cause of aging for yeast as well as the role of Sir2 in epigenetic changes driven by genome instability. In 1999 he was recruited to Harvard Medical School where he has been teaching aging biology and translational medicine for aging for the past 16 years. He was also on TIME magazine’s 2014 list of the “100 most influential people in the world”.


0:00 Introduction
1:15 Direction toward anti-aging research
2:11 How aging involves information loss
3:38 Our next evolutionary steps
5:53 Genetic pathways that respond to adversity
7:49 Stress differences
9:00 The Horvath clock
11:30 Main demographics for anti-aging research
12:54 Medical community response to the research
14:33 Lifestyle/supplement example
16:16 Organism survival circuits
17:40 Sirtuins and the epigenome
19:34 Accumulation of senescent cells
20:50 Regrowth of optic nerve cells
23:40 Self-correction response pathway
26:32 Anti-aging as a beacon of hope and productivity
28:42 Demands on Dr. Sinclair’s research
30:52 Horvath clock testing
32:50 Message to all people

This was an enjoyable episode, and book, that is right on the forefront of aging research and technology. Dr. Sinclair is very active in this space, and it shows. You can check out his website, the book on Amazon, or some of his research.


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