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This Harvard Professor Explains the Secret to Aging in Reverse | David Sinclair on Health Theory

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Harvard professor David Sinclair believes that not only can we slow aging down, we can actually reverse it. On this episode of Health Theory with Tom Bilyeu, David Sinclair explains the three levels of aging, and what can be done on each level. He describes the lifestyle changes that slow aging down, the drug treatments that begin to stop aging, and experimental new procedures that may actually reverse aging once they are fully developed.


David explains the information theory of aging [0:59]
David explains the difference between genes and the epigenome [2:17]
David describes the way that cell stress causes aging [5:20]
David explains what proteins are and how they work [6:40]
David recommends lifestyle changes to slow down or reverse aging [9:14]
David recommends stressing the system by consistent fasting [10:52]
David explains why we don’t live as long as whales [15:01]
David describes resetting the biological clock [16:16]
David explains how to tell when someone is going to die [18:47]
David explains why people are taking metformin [20:03]
David shares his regimen of exercise and metformin [24:18]
David advocates cold exposure [25:28]
David explains work he’s done to try to reset the aging clock [29:01]
David explains why you don’t want to turn the cellular clock back too far [31:37]
David describes the actual process of reversing aging in masses of cells [33:20]
David talks about some results with mice that appear to reverse aging [36:40]
David shares his father’s story of metformin and NMN use [38:10]
David explains the effects of resveratrol [39:07]
David describes the kinds of testing he advocates [43:13]
David shares the impact he wants to have on the world [45:44]



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